Table 3.
Comparison of characteristics between solid organ, hematopoietic stem cell transplantation recipients, and non-transplant individuals among total 1,586 patients with CMV disease except CMV syndrome
| Characteristics | No transplantation (N = 1,258) | SOT (N = 283) | HSCT (N = 45) | P-value |
|---|---|---|---|---|
| Age, years | 42.1 ± 26.8 | 43.9 ± 17.0 | 40.9 ± 16.9 | 0.501 |
| ≥ 40-year-old | 765 (60.8) | 195 (68.9) | 25 (55.6) | 0.026 |
| Sex, male | 699 (55.6) | 148 (52.3) | 21 (46.7) | 0.331 |
| Co-morbid illnessa | 636 (50.6) | 97 (34.3) | 18 (40.0) | 0.031 |
| Type 2 DM | 375 (29.8) | 78 (27.6) | 14 (31.1) | 0.849 |
| ESRD on dialysis | 83 (6.6) | 2 (0.7) | 1 (2.2) | 0.017 |
| Chronic heart diseases | 64 (5.1) | 8 (2.8) | 3 (6.7) | 0.125 |
| Chronic liver diseases | 38 (3.0) | 10 (3.5) | 4 (8.9) | 0.367 |
| Chronic lung diseases | 93 (7.4) | 5 (1.8) | 1 (2.2) | 0.025 |
| HIV-1 infection | 20 (1.6) | 0 (0) | 0 (0) | — |
| Transplant organ | — | |||
| Single | — | 277 (97.9) | — | |
| Kidney | — | 192 (67.8) | — | |
| Liver | — | 56 (19.8) | — | |
| Heart | — | 25 (8.8) | — | |
| Lung | — | 2 (0.7) | — | |
| Pancreas alone | — | 2 (0.7) | — | |
| Multi-organ | — | 6 (2.1) | — | |
| CMV diagnosisb | 0.248 | |||
| B25 | 3 (0.2) | 0 (0) | 0 (0) | |
| B25.0 | 89 (7.1) | 6 (2.1) | 0 (0) | |
| B25.1 | 101 (8.0) | 4 (1.4) | 0 (0) | |
| B25.2 | 4 (0.3) | 0 (0) | 0 (0) | |
| B25.8 | 465 (37.0) | 80 (28.3) | 20 (44.4) | |
| B25.9 | 596 (47.4) | 193 (68.2) | 25 (55.6) | |
| Intervals between transplantation and CMV casesc, months | — | 3.4 ± 2.7 | 2.2 ± 2.0 | 0.007 |
| Transplant organs | ||||
| Kidney | — | 3.4 ± 2.7 | — | |
| Liver | — | 3.4 ± 2.8 | — | |
| Heart | — | 3.4 ± 2.5 | — | |
| Lung | — | 8.1 ± 3.0 | — | |
| Pancreas alone | — | 5.0 ± 0.8 | — | |
| Multi-organ | — | 2.9 ± 2.3 | — | |
| CMV diagnosisb | ||||
| B25.0 | — | 6.2 ± 3.5 | — | |
| B25.1 | — | 2.0 ± 1.8 | — | |
| B25.8 | — | 3.9 ± 2.7 | 2.2 ± 1.2 | |
| B25.9 | — | 3.2 ± 2.6 | 2.3 ± 1.9 | |
| All-cause death | 207 (16.5) | 18 (6.4) | 13 (28.9) | <0.001 |
Data are expressed as mean ± standard deviation or number (percentage). aSome patients had several illnesses. bBy WHO ICD-10 codes, version 2016 (B25: cytomegaloviral disease, B25.0: cytomegaloviral pneumonitis, B25.1: cytomegaloviral hepatitis, B25.2: cytomegaloviral pancreatitis, B25.8: other cytomegaloviral diseases, B25.9: cytomegaloviral disease, unspecified). cIndicate CMV disease except CMV syndrome. Aberrations: CMV, cytomegalovirus; DM, diabetes mellitus; ESRD, end stage renal disease; HIV-1, human immunodeficiency virus-1; HSCT, hematopoietic stem cell transplantation; f/u, follow-up; ICD-10, International Statistical Classification of Diseases and Related-Health Problems 10th Revision; SOT, solid organ transplantation, WHO, World Health Organization