Table 2.

Summary of effects of developmental POP exposure on glutamatergic and GABAergic transmission.

Toxicant	Dose	Route of Exposure	Species	Sex	Brain region	Exposure	Effects on synaptic plasticity	Reference
TCDD	200, 800 ng/kg	Gavage	Rat	Females only	Hippocampus, Cortex	GD 15	Decreased NR2B NMDAR; Increased NR2A NMDAR	Kakeyama et al., 2001
	700 ng/kg	Gavage	Rat	Males only	Hippocampus	GD 15	Decreased NR1 NMDAR	Nayyar et al., 2003
	700 ng/kg	Gavage	Rat	Males only	Hippocampus	GD 14	Decreased LTP; Decreased NR2B NMDAR; Incresed NR2A NMDAR	Wormley et al., 2004
	100, 700 ng/kg	Gavage	Rat	Males and Females Combined	Barrel cortex	GD 15	Decreased activity; Decreased NR2B NMDAR; Decreased GluR1 AMPAR	Hood et al., 2006
	700 ng/kg	Gavage	Rat	Males only	Cortex	GD 18	Decreased glutamate transmission	Tomasini et al., 2012
	100 nM	In vitro	Rat	Males only	Hippocampus	PND 26-47	Decreased EPSPs	Hong et al., 1998
	20 nmol/L	In vitro	Rat	Not specified	Cortex	GD 17 primary cortical neurons	Decreased activity	Lin et al., 2008
	20 nM	In vitro	Rat	Not specified	Cortex	GD 17 primary cortical neurons	Increased NR2A NMDAR	Lin et al., 2009
	1 μg/kg	Diet	Rat	Males vs. Females	Preoptic area	GD 15	Decreased GAD 67 expression	Hays et al., 2002
B(a)P	25, 150 μg/kg/d	Gavage	Rat	Not specified	Hippocampus, Cortex	GD 14-17	Decreased NR2A and NR2B NMDARs; Decreased GluR1 AMPAR; Decreased inward currents	Brown et al., 2007
	300 μg/kg/d	Gavage	Rat	Males only	Cortex	GD 14-17	Decreased NR2B NMDAR and activity	McCallister et al., 2008
	100 μg/m3;4 h/day	Inhalation	Rat	Males only	Hippocampus	GD 11-21	Decreased NR1 NMDAR; Decreased LTP	Wormley et al., 2004
	100 μg/m3; 4 h/day	Inhalation	Rat	Males only	Hippocampus	GD 14	Decreased LTP; Decreased NR2B NMDAR; Incresed NR2A NMDAR	Wormley et al., 2004
PCB 95	200 nM	In vitro	Rat	Males and Females Combined	Hippocampus	Primary cell cultlures	Increased mEPSCs	Lesiak et al., 2014
	6 mg/kg/d	Diet	Rat	Male and Females Combined	Auditory Cortex	GD 5-PND21	Disrupted excitation/inhibition balance	Kenet et al., 2007
PCB Mixture	6 mg/kg/d	Diet	Rat	Male and Females Combined	Auditory Cortex	Gestation and Lactation	Increased spontaneous and miniature IPSCs; EPSCs not affected; Disrupted excitation/inhibition balance	Lee et al., 2021
PCB 52, 138, 180	1 mg/kg/d	Gavage	Rat	Males vs. Females	Cerebellum	GD 7-PND21	PCB 138 and 180 decreased NR1 NMDAR; Increased extracellular GABA; Decreased glutamate signaling	Boix et al., 2010
22 PCB congeners	0.3 - 10 μM	In vitro	Xenopus laevis oocytes	Females	N/A	N/A	GABA(A) receptor activation	Fernandes et al., 2010
PCB 28, 52, 101, 138, 153, 180	0.3 - 10 μM	In vitro	Xenopus laevis oocytes	Females	N/A	N/A	GABA(A) receptor potentiation	Fernandes et al., 2010
PCB 47, PBDE 47, 6-OH-PBDE 47	0.3 - 10 μM	In vitro	Xenopus laevis oocytes	Females	N/A	N/A	GABA(A) receptor potentiation	Hendriks et al., 2010
PBDE 47	6.8 mg/kg	Gavage	Mouse	Males only	Hippocampus	PND 10	Decreased LTP; Decreased NR2B NMDAR; Decreased GluR1 AMPAR	Dingemans et al., 2007
PBDE 209	20 μM	Gavage	Rat	Males and Females Combined	Hippocampus	Before and after gesation	Decreased input/output functions; Decreased paired-pulse ratio; Decreased LTP	Xing et al., 2009
PBDE 209	0.05 - 2.0 μM	In vitro	Rat	Not specified	Hippocampus	PND 0 primary hippocampal neurons	Decreased inward currents	Xing et al., 2010