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. Author manuscript; available in PMC: 2021 Dec 17.
Published in final edited form as: Nat Nanotechnol. 2021 Jun 17;16(8):942–951. doi: 10.1038/s41565-021-00923-2

Figure 4. Biodistribution of nanodecoys after inhalation.

Figure 4.

(a) Schematic showing study design of nanodecoy inhalation in CD1 mice. Created with BioRender.com. (b) Corresponding quantitative results from (c) of DiD-labeled nanodecoys in heart, lung, liver, kidney, and spleen tissues. Data are shown as mean ± SD, n=3 animals. At least three images were taken. (c) Representative confocal images of DiD-labeled nanodecoys (red) in tissue sections. (d) Representative confocal images showing nanodecoys in lung tissues co-localizing with lung cells (AQP5, SFTPC) and macrophages (CD68) 24 hrs post-inhalation. Five images were taken. (e) Quantification of the percent of nanodecoy-positive macrophages. Data are shown as mean ± SD, n=3 animals. Scale bars, 200 μm for Figure 4c–d.