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. Author manuscript; available in PMC: 2022 Sep 1.
Published in final edited form as: Trends Pharmacol Sci. 2021 Jun 27;42(9):715–728. doi: 10.1016/j.tips.2021.05.007

Figure 2.

Figure 2.

A) Schematic diagram illustrating the ADME within the human circulation system. B) Schematic diagram illustrating the various mechanism of drug-induced toxicity. D: drug, D’: drug metabolite.