Table 1.
Antibacterial Activities Against Wild-Type E. coli and ESKAPE Pathogens (MIC, μg/mL)a
| Species | MRSA | E. coli | K. pneu. | Enterob. | A. baum. | P. aerug. b |
|---|---|---|---|---|---|---|
| Strain | AG038 | AG001 | AG215 | AG290 | AG225 | AG220 |
| Propylamycin 1 | 1–2 | 1 | 0.25–0.5 | 0.5 | 1–2 | 8–16 |
| Paromomycin 2 | 2 | 2–4 | 1 | 2 | 2–4 | >128 |
| Lividomycin B 3 | 4 | 4–8 | 2 | 2 | 4 | 4 |
| 8 | 2 | 2 | 1 | 1 | 2 | 4 |
| 9 | 1–2 | 2–4 | 1 | 4 | 4 | 4 |
| 10 | 2 | 2–4 | 2 | 8 | 8 | 16 |
| 11 | 1 | 1 | 1 | 1 | 2 | 8 |
| 12 | 2 | 4 | 2–4 | 2–4 | 2–4 | 128 |
| 13 | 2 | 2–4 | 2 | 2 | 2 | 4 |
| 14 | 2 | 1–2 | 1 | 1 | 2 | 4 |
| 15 | 4 | 4 | 2 | 2 | 32 | >64 |
| Gentamicin | 1–2 | 0.5–1 | 0.25 | 0.25 | 0.5–1 | 1 |
| Plazomicin | 2 | 1 | 0.5 | 0.5 | 2 | 2–4 |
a)
All values were determined in duplicate using twofold dilution series.
b)
P. aeruginosa carries a chromosomal APH(3’) gene, which principally affects the 3’-hydroxy group.