Table 2.

Activities Against E. coli in the Presence of Specific Resistance Determinants (MIC, μg/mL)^a

Resistance det	WT-parental	APH(3’)-Ia	APH(3’)-IIa	APH(3’)-IIb	APH(3’)-VI	AAC(3)-IV	ArmA	RmtB
Strain	EC026	EC189	EC191	EC125	EC141	EC118	EC102	EC103
Propylamycin 1	0.25–0.5	64–128	0.5–1	0.5–1	0.5	1–2	0.5	0.5
Paromomycin 2	0.5–1	128	64	64–128	64	1–2	0.5–1	0.5–1
Lividomycin B 3	1–2	>128	1–2	0.5	1	2	1	1–2
8	0.5–1	2–4	1–2	0.5–1	0.5–1	2–4	2–4	2–4
9	0.5–1	4	1–2	0.5–1	0.5	2	1–2	2
10	1–2	8	4	4	1–2	8	4	4–8
11	0.5–1	2	0.5–1	0.5	0.25	2	2	4
12	1	8–16	2–4	2–4	0.5–1	16	8	4
13	0.5–1	2–4	1–2	0.5–1	0.5	4	4	2–4
14	1	>128	1–2	0.5–1	1	2–4	1	2
15	2	>32	4	4	1–2	16	4	4–8

^a)All values were determined in duplicate using twofold dilution series.