Table 3.
Activities Against E. coli in the Presence of Acquired Resistance Determinants (MIC, μg/mL)a
| Resistance det | WT-parental | AAC(3)-II | AAC(3’)-IV | APH(3’)-I | APH(3’)-II | AAC(6’) |
|---|---|---|---|---|---|---|
| Strain | AG001 | AG003 | AG173 | AG163 | AG166 | AG175 |
| Propylamycin 1 | 1 | 2 | 2 | >128 | 1–2 | 2–4 |
| Paromomycin 2 | 2–4 | 4 | 8–16 | >128 | >128 | 4 |
| Lividomycin B 3 | 4–8 | 8 | 8–16 | >128 | 8 | 8 |
| 8 | 2 | 4–8 | 4 | 16 | 2–4 | 4–8 |
| 9 | 2–4 | 2–4 | 4 | 4–8 | 4 | 4 |
| 10 | 2–4 | 4–8 | 8–16 | 16–32 | 4 | 4–8 |
| 11 | 1 | 2 | 4–8 | 4–8 | 2 | 2–4 |
| 12 | 4 | 4–8 | 32 | 32 | 16–32 | 4–8 |
| 13 | 2–4 | 4–8 | 8 | 8–16 | 4 | 4–8 |
| 14 | 1–2 | 4 | 4–8 | >128 | 4 | 4 |
| 15 | 4 | 8 | 4 | >32 | 16 | 8–16 |
a)
All values were determined in duplicate using twofold dilution series.