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. Author manuscript; available in PMC: 2022 Aug 13.
Published in final edited form as: ACS Infect Dis. 2021 Jun 11;7(8):2413–2424. doi: 10.1021/acsinfecdis.1c00158

Table 4.

Antiribosomal Activities and Selectivities (IC50, μM).

Antiribosomal Activity Selectivity
wt Mit13 A1555G Cyt14 Mit13 A1555G Cyt14
Propylamycin 1 0.022±0.005 150±51 56±17 61±14 6818 2545 2773
Paromomycin 2 0.033±0.006 128±67 12±3 38±6 3879 364 1152
Lividomycin B, 3 0.084±0.030 182±35 24±1 98±12 2167 286 1140
8 0.14±0.04 62±24 38±9 9.0±1.6 443 271 64
9 0.091±0.008 55±10 36±8 31±2 604 396 341
10 0.46±0.09 41±12 25±4 24±2 89 54 52
11 0.034±0.014 505±208 118±12 175±14 14991 3471 5147
12 0.078±0.007 318±69 189±66 194±15 4077 2423 2487
13 0.090±0.018 40±16 10±4 6.1±0.4 444 111 68
14 0.064±0.005 204±25 93±31 305±58 3188 1453 4766
15 0.40±0.04 89±6 54±6 68±3 222 135 170
Plazomicin 0.065±0.020 107±33 5.9±2.1 299±82 1633 90 4569
Gentamicin 0.029±0.009 15±4 0.80±1.5 74±41 517 28 2552