Table 1.

Overview of lncRNAs discussed in this article.

IncRNA	Interactions and Functions	Promotes…	References
BGL3	Binds PARP1 and BARD1, promoting retention of the BRCA1-BARD1 complex at DSBs	HR	[32]
DDSR1	Interacts with BRCA1 and hnRNPUL1 to regulate HR	HR	[27]
PRLH1	Interacts with RNF169, replacing 53BP1 from ubiquitinylated chromatin	HR	[31]
TERRA	Interacts with RAD51 at telomeres to form R-loops	HR (at telomeres)	[35,94]
HITT	Blocks the ATM binding site for the MRN complex	NHEJ	[24,100]
LINP1	Binds to Ku to stabilize the synaptic complex	NHEJ	[13,97]
LRIK	Interacts with Ku, enhancing the efficiency of NHEJ	NHEJ	[33]
SNHG12	Mediates the interaction between DNA-PK and Ku	NHEJ	[23]
SNHG17	Binds NONO Causes upregulation of RING1, which induces RAD51 degradation	NHEJ	[34]
GUARDIN	Prevents chromosome end-to-end fusion by sequestering microRNA23a Promotes BRCA1-BARD1 complex formation	HR and NHEJ	[26]
HITTERS	Promotes binding of MRE11 to RAD50	Cell survival	[25]
Linc00312	Binds to DNA-PKcs to prevent recruitment to Ku80	Apoptosis	[28]
Lnc-bc060912	Interacts with PARP1 and NPM1	Cell survival	[29]
NEAT1	Binds DBHS proteins and FUS Forms paraspeckles upon activation of p53 Is involved in transcriptional activation of DNA repairgenes	Genome stability	[46,51,102,103]
NEAT2/MALAT1	Forms a complex with PARP1 and LIG3 to aid in alternative NHEJ Binds SFPQ, which renders it unable to sequester oncoprotein PTBP2	Cell survival	[30,108]