Table 2.
Expression of TLR2, TLR4 and FXR in normal oesophageal squamous epithelium and in mild and severe oesophagitis
| Protein/location | Normal epithelium (histoscore) | Mild Esophagitis (histoscore) | Severe Esophagitis (histoscore) | ||
|---|---|---|---|---|---|
| Median (IQR) | Median (IQR) | p | Median (IQR) | p | |
| TLR2 | |||||
| Basal cytoplasm | 133 (116–160) | 187 (167-200) | <0.05 | 200 (187–241) | <0.01 |
| Basal nuclei | 80 (67–90) | 77 (60–93) | 87 (70–97) | 0.36 | |
| Superficial cytoplasm | 73 (63–83) | 80 (73–90) | 0.29 | 90 (77–111) | <0.01 |
| Superficial nuclei | 67 (60–67) | 80 (63–87) | 83 (62–88) | 0.17 | |
| TLR4 | |||||
| Basal cytoplasm | 193 (150–193) | 233 (200–267) | 231 (137–278) | 0.22 | |
| Basal nuclei | 233 (210–233) | 167 (120–260) | 233 (122–285) | 0.22 | |
| Superficial cytoplasm | 139 (90–139) | 93 (87–167) | 120 (85–177) | 0.90 | |
| Superficial nuclei | 194 (180–194) | 180 (160–210) | 210 (170–255) | 0.34 | |
| FXR | 62 (36–62) | 100 (47-147) | 0.20 | 133 (92–195) | <0.01 |
p-values represent the comparison with normal squamous epithelium. There were no significant differences between mild and severe esophagitis
TLR Toll-like receptor, FXR Farnesoid X receptor, ns not significant