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. 2021 Mar 1;479(2):325–335. doi: 10.1007/s00428-021-03054-0

Table 4.

Multivariate analysis

Variable RFS PFS OS
HR (95% CI) p HR (95% CI) p HR (95% CI) p
Age
  ≤ 72 1.00 1.00 1.00
  > 72 3.23 (1.73–6.04) <0.001 3.08 (1.26–7.54) 0.014 7.38 (3.63–15.01) <0.001
Sex - - - -
  Female 1.00
  Male 0.78 (0.35–1.77) 0.557
Prior UC - - - -
  Yes 1.00
  No 1.62 (0.82-3.21) 0.166
Concomitant pT1 - - - -
  No 1.00
  Yes 1.49 (0.86–2.60) 0.160
CIS focality - - - -
  Unifocal 1.00
  Multifocal 1.12 0.62–2.01) 0.704
Smoking status - - - -
  Never 1.00
  Former 0.54 (0.12–2.45) 0.420
  Current 3.91 (1.59–9.62) 0.003
BCG therapy - - - -
  No 1.00
  Yes 0.62 (0.35–1.09) 0.099
Recurrence at first FU - - - -
  No 1.00
  Yes 1.50 (0.76–2.97) 0.240

p values < 0.05 were considered significant and are shown in italics

CI, confidence interval; FU, follow-up, HR, hazard ratio, OS, overall survival, PFS, progression-free survival, RFS, recurrence-free survival; UC, urothelial carcinoma