Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Aug 14;7:215. doi: 10.1038/s41420-021-00595-w

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 1 — A Volcano plot of circRNA microarray analysis revealed the des-regulated circRNAs within the cervical cancer tissue and adjacent normal tissue. B Heatmap of circRNA microarray analysis. C Schematic diagram demonstrated the generation of circARHGAP12 (hsa_circ_0000231, 796-bp) from exon-3 and exon-2 of ARHGAP12 gene through back splicing. D Sanger sequencing revealed the conjunction sites of circARHGAP12 back splicing. E RNA persistence testing using RNase R showed the expression of circular transcript (circARHGAP12) and linear mRNA (ARHGAP12 mRNA) detected using RT-PCR. F In the collected cervical cancer specimens’ group, circARHGAP12 expression was analyzed using RT-PCR. G Survival analysis using the Kaplan–Meier survival curve and the log-rank test demonstrated the survival rate of patients with higher or lower circARHGAP12 levels. P values were calculated by Student’s t-test. **p < 0.01.