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. 2021 Aug 14;11(8):146. doi: 10.1038/s41408-021-00537-w

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — A Cytotoxic activity of untransduced NKAE cells and memory T cells (CD45RA⁻ T cells), CAR-NKAE cells, and memory CAR-T cells against different MM cell lines. Results are shown as mean ± SEM of four independent experiments. *P < 0.05 compared to untransduced cells (NKAE and memory T cells) and memory CAR-T cells. B Cytotoxicity of NKAE and CAR-NKAE against primary MM cells from bone marrow sample at different E:T ratios (triplicates). C Plots representing the relationship between the differences in the degree of killing (between NKAE cells and CAR-NKAE cells) and the expression of NKG2DL (MICA, ULBP-1, ULBP-2/5/6, and ULBP-3) in 3 MM cell lines with different expression of NKG2DL. D Time-lapse experiments were performed, U-266 MM cells (green) were destroyed by CAR-NKAE cells (red) with only 20 min of exposure. After 3 h, MM cells were destroyed and released the green fluorescent probe.