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. 2021 Aug 14;11(8):144. doi: 10.1038/s41408-021-00536-x

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Quantification and statistical analysis of the expression of IL-10RA and IL-10RB on blast cells from AML patients or bone marrow mononuclear cells (BMMNCs) from healthy donors (HD). b Quantification and statistical analysis of CD107a in VEC-T or IL-10 CAR-T cells (GFP⁺) after co-incubated with blast cells at an E:T ratio of 1:1 for 6 h (n = 3; **p < 0.01; ***p < 0.001; P, patient). c Direct lysis of T cells toward blast cells after cocultured for 48 h at the indicated E:T ratio (1:4, 1:2, 1:1, 2:1, 4:1). Flow cytometry analysis of the percentage of CD34⁺ cells, which represented for the residue of blast cell (n = 5, two-way ANOVA; ****p < 0.0001) d Correlation analysis between the specific lysis and the level of IL-10RA expression (Spearman correlation analysis, n = 12; **p < 0.01). e Correlation analysis between the specific lysis and the level of IL-10RB expression (Spearman correlation analysis, n = 12). f ELISA data showed the cytokines released by T cells after co-incubated with blasts cells for 48 h at the E:T ratio of 1:1 (n = 5; **p < 0.01; ***p < 0.001).