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. 2021 Aug 14;11(8):144. doi: 10.1038/s41408-021-00536-x

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Schematic diagram of the experimental regimen for validating the efficiency of IL-10 CAR-T. b Statistical analysis of body weight of each group measured at indicated days (n = 8; two-way ANOVA; *p < 0.05). c Pathological analysis of the bone marrow, liver, and spleen of the mice at 21 days after leukemia cells inoculation. d Flow cytometry analysis of the proportion of human CD3⁺ T cells in the peripheral blood of mice at day 21 and 28 after leukemia cells inoculation (n = 5; **p < 0.01; ***p < 0.001). e Flow cytometry analysis of the proportion of human CD33⁺ AML cells in the peripheral blood of mice at day 21 and 28 after leukemia cells inoculation (n = 5; n.s. no significant; *p < 0.05). f Representative bioluminescence images of each group collected from indicated days. g Statistical analysis of the bioluminescence intensity of (g) (n = 5; *p < 0.05; **p < 0.01; ***p < 0.001). h Kaplan–Meier survival curves for mice (n = 8; Log-rank test; ***p < 0.001).