Fig. 5.

Panobinostat or entinostat does not substantially affect the number of inhibitory interneurons in ipsilateral AGm. Top left panel, panobinostat- or entinostat-treated mice have comparable number of parvalbumin-positive (PV+) neurons in ipsilateral (I) and contralateral (C) medial premotor area (AGm, medial agranular cortex) (n = 6 per group; p > 0.05 for I vs. C comparisons within each experimental group). Top right panel, comparable number of DAPI-stained nuclei was documented within the same subareas of AGm in experimental groups. Bottom panel, a representative immunofluorescence confocal microscopy image of a mouse brain section on day 42 after stroke. PV signal is depicted in green and cell nuclei (stained with DAPI) in blue. Note that the representative Cresyl violet-stained brain section is shown to illustrate the imaged medial premotor area (red boxes). Pano 3.0 3 mg/kg panobinostat; Pano 10.0 10 mg/kg panobinostat; Entino 1.7 1.7 mg/kg entinostat; Entino 5.0 5.0 mg/kg entinostat