Fig. 7.

Inhibition of brain histone deacetylases after peripheral administration of panobinostat or entinostat. Following photothrombotic stroke, mice were treated with panobinostat (3, 10 and 30 mg/kg) or entinostat (1.7, 5 and 15 mg/kg) every other day starting on post-stroke day 5 and one day after the last dosing animals were euthanized to obtain the peri-infarct cortical tissue (post-stroke day 16) for Western Blotting. Left and right panels, representative immunoblotting experiments documenting acetylation status of histone 3 after panobinostat (left panel) or entinostat (right panel) treatments. Pano 3.0 3 mg/kg panobinostat; Pano 10.0 10 mg/kg panobinostat; Pano 30.0 30 mg/kg panobinostat; Entino 1.7 1.7 mg/kg entinostat; Entino 5.0 5.0 mg/kg entinostat; Entino 15.0 15 mg/kg entinostat