Table 3.
Associations between clinical factors with OS and RFS in 212 COAD patients
| Variable | OS* | RFS# | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Patients | MST (days) | HR (95% CI) | Log-rank P | Patients | MRT (days) | HR (95% CI) | Log-rank P | ||||
| Gender | 0.801 | 0.467 | |||||||||
| Male | 137 | NA | 1 | 111 | NA | 1 | |||||
| Female | 75 | NA | 0.934 (0.552-1.582) | 64 | NA | 1.302 (0.637-2.661) | |||||
| Age (years) | 0.536 | 0.915 | |||||||||
| ≤65 | 137 | NA | 1 | 109 | NA | 1 | |||||
| >65 | 75 | NA | 1.174 (0.707-1.950) | 66 | NA | 1.040 (0.505-2.143) | |||||
| CEA (ng/ml) | 0.169 | 0.462 | |||||||||
| 1-5 | 113 | NA | 1 | 101 | NA | 1 | |||||
| >5 | 93 | NA | 1.424 (0.858-2.363) | 70 | NA | 0.759 (0.364-1.585) | |||||
| Missing | 6 | 4 | |||||||||
| TNM stage | <0.0001 | 0.039 | |||||||||
| I | 29 | NA | 1 | 30 | 1 | ||||||
| II | 57 | NA | 0.742 (0.209-2.629) | 58 | 0.499 (0.144-1.725) | ||||||
| III | 89 | NA | 2.469 (0.864-7.060) | 87 | 1.625 (0.612-4.311) | ||||||
| IV | 27 | 405 | 22.253 (7.607-65.098) | 0 | |||||||
| Location | 0.806 | 0.627 | |||||||||
| Right | 102 | NA | 1 | 86 | NA | 1 | |||||
| Left+both | 110 | NA | 0.929 (0.565-1.529) | 89 | NA | 1.191 (0.587-2.418) | |||||
| Tumor type | 0.691 | 0.358 | |||||||||
| Invasive | 11 | NA | 1 | 7 | NA | 1 | |||||
| ulcerative | 153 | NA | 1.511 (0.367-6.221) | 126 | NA | 25897.646 (0-2.4428763792086E+116) | |||||
| mass | 42 | NA | 1.203 (0.267-5.428) | 36 | NA | 17555.202 (0-1.657925218057E+116) | |||||
| Missing | 6 | 6 | |||||||||
| Tumor differentiation | 0.019 | 0.639 | |||||||||
| Well | 10 | NA | 1 | 10 | NA | 1 | |||||
| Moderate | 160 | NA | 1.451 (0.352-5.993) | 138 | NA | 0.582 (0.175-1.941) | |||||
| Poor | 42 | NA | 3.076 (0.710-13.318) | 27 | NA | 0.724 (0.173-3.031) | |||||
| Tumor thrombus | <0.0001 | 0.095 | |||||||||
| No | 185 | NA | 1 | 163 | NA | 1 | |||||
| Yes | 26 | 660 | 4.571 (2.568-8.134) | 12 | NA | 2.389 (0.833-6.858) | |||||
| Missing | 1 | ||||||||||
| Tumor size (cm) | 0.236 | 0.573 | |||||||||
| <5 | 90 | NA | 1 | 75 | NA | 1 | |||||
| ≥5 | 116 | NA | 0.739 (0.447-1.221) | 95 | NA | 0.817 (0.404-1.654) | |||||
| Missing | 6 | 5 | |||||||||
| Tumor number | 0.138 | 0.160 | |||||||||
| Single | 205 | NA | 1 | 170 | NA | 1 | |||||
| Two | 7 | 1917 | 2.119 (0.768-5.844) | 5 | 1900 | 2.687 (0.64-11.291) | |||||
| Lymph node | <0.0001 | 0.001 | |||||||||
| Negative | 120 | NA | 1 | 107 | NA | 1 | |||||
| Positive | 91 | NA | 3.546 (2.075-6.061) | 68 | NA | 3.411 (1.633-7.126) | |||||
| Missing | 1 | ||||||||||
| Radical resection | <0.0001 | ||||||||||
| Yes | 175 | NA | 1 | ||||||||
| No | 37 | 481 | 11.536 (6.836-19.469) | ||||||||
| Tumor transfer | <0.0001 | ||||||||||
| No | 179 | NA | 1 | ||||||||
| Yes | 33 | 401 | 14.344 (8.376-24.565) | ||||||||
| Nerve infiltration | 0.173 | 0.152 | |||||||||
| No | 207 | NA | 1 | 173 | NA | 1 | |||||
| Yes | 4 | 1079 | 2.572 (0.628-10.540) | 2 | 412 | 3.864 (0.525-28.419) | |||||
| Missing | 1 | ||||||||||
| Postopetative chemotherapy | 0.833 | 0.744 | |||||||||
| No | 69 | NA | 1 | 59 | NA | 1 | |||||
| Yes | 124 | NA | 1.061 (0.610-1.846) | 100 | NA | 0.887 (0.43-1.828) | |||||
| Missing | 19 | 16 | |||||||||
| CXCL1 | 0.444 | 0.738 | |||||||||
| Negative | 36 | NA | 1 | 31 | NA | 1 | |||||
| Positive | 166 | NA | 0.788 (0.427-1.452) | 144 | NA | 0.859 (0.352-2.094) | |||||
Notes: * 202 patients had OS information; # 175 patients underwent radical surgery, of which 171 had RFS information; MST: median total survival; MRT: median recurrence time, NA: Not available.