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. 2021 Jul 29;3(3):fcab172. doi: 10.1093/braincomms/fcab172

Figure 3.

Figure 3

Changes in myelin linearity of intra-gyral white matter. Directionality of the myelin basic protein (MBP)- and 2′,3′-Cyclic-nucleotide 3′-phosphodiesterase (CNPase)-labelled myelin in the lower first and second intragyral white matter tracts (IGWM 1 and 2, top and middle panels) of the sham-ischaemia (white circles), ischaemia-vehicle (black circles, n = 9), ischaemia-Epo (red triangles, n = 8), ischaemia-hypothermia (blue triangles, n = 8), and ischaemia-Epo-hypothermia (green diamonds, n = 8) groups at 7 days after global cerebral ischaemia. Ischaemia reduced the linearity of myelin, with a lower percentage of MBP- and CNPase-myelin aligned to peak direction from −5 to +5° (bottom panel). Data are presented as mean ± SD. Analysis by 1-Factor ANOVA with ischaemia treated as an independent variable, and 3-Factor ANOVA with hypothermia and rEpo as independent variables, and regions treated as a repeated measure. *P < 0.05 versus sham-ischaemia; $P < 0.05 effect of hypothermia.