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. 2021 Jun 29;3(3):fcab141. doi: 10.1093/braincomms/fcab141

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© The Author(s) (2021). Published by Oxford University Press on behalf of the Guarantors of Brain.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Pathway scoring analysis. Graph showing results from the pathway scoring analysis performed using Advanced Analysis nSolver software. Pathway activation scores are plotted as a function of the different treatment type and time points (H 2MIU D1, D8, D64 = high-Treg-responders at D1, D8 and D64; L 2MIU D1, D8, D64 = low-Treg-responders at D1, D8 and D64 and Placebo at D1, D8 and D64). An evident downregulation of several inflammatory pathways is demonstrated in both high and low-Treg-responders although baseline differences were observed between the two treated subgroups.