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The homology-modeled ADAM17 ectodomain, generated using the snake venom homolog VAP1 as template and with CANDIS and juxtamembrane regions added, complexed to the ACE2, available from RCSB as id 6M1D, and embedded in a POPC bilayer as described in methods; inset orientation of the RK_K side chains and 652FWDF655 CANDIS segment relative to the plane of the membrane.
