Table 3.
Multivariable logistic regression model for major adverse kidney events at the time of hospital discharge by renin tertiles
| Variable | Odds ratio with 95% confidence intervala | p value |
|---|---|---|
| Renin tertile (vs. first tertile) | ||
| Second tertile | 2.51 (1.08–5.80) | 0.032 |
| Third tertile | 2.33 (1.01–5.44) | 0.050 |
| Age (vs. first quartile) | ||
| Second quartile | 0.32 (0.12–0.86) | 0.023 |
| Third quartile | 0.31 (0.10–0.95) | 0.040 |
| Fourth quartile | 0.30 (0.08–1.11) | 0.071 |
| Sex (male vs. female) | 0.63 (0.32–1.25) | 0.188 |
| Race (vs. white) | ||
| Black | 2.30 (0.74–7.15) | 0.150 |
| Other | 1.20 (0.39–3.68) | 0.748 |
| Baseline eGFR, per 1 ml/min/1.73 m2 | 1.02 (0.99–1.04) | 0.173 |
| Charlson comorbidity index, per 1-unit | 1.64 (1.35–2.00) | < 0.001 |
| ICU (vs. surgical) | ||
| Medical | 2.82 (1.30–6.12) | 0.009 |
| Cardiac | 2.12 (0.69–6.48) | 0.189 |
| Site (UK vs. UTSW) | 1.28 (0.54–3.02) | 0.572 |
| Non-renal APACHE II, per 1-unit | 1.02 (0.98–1.06) | 0.246 |
| NGAL, per 1-log unit | 2.93 (2.02–4.23) | < 0.001 |
eGFR estimated glomerular filtration rate, ICU intensive care unit, UK University of Kentucky, UTSW University of Texas Southwestern, APACHE II Acute Physiology and Chronic Health Evaluation II, NGAL neutrophil gelatinase-associated lipocalin
aFixed model developed using hypothesized predictors of outcome and clinically relevant imbalances in renin tertiles