. Author manuscript; available in PMC: 2022 Jul 1.

Published in final edited form as: J Pediatr Gastroenterol Nutr. 2021 Jul 1;73(1):67–72. doi: 10.1097/MPG.0000000000003101

Table 1.

Adjusted PROMIS^® Pediatric mean scores^** by ulcerative colitis disease activity^*

PROMIS Pediatric Domain^**	Pediatric Ulcerative Colitis Disease Activity Index (PUCAI) Category^*; mean (95% CI; SE)			p value (for all PUCAI categories)
PROMIS Pediatric Domain^**	Remission	Mild	Moderate/Severe	p value (for all PUCAI categories)
Anxiety	52.1 (45.8 to 58.4; 3.2)	56.0 (49.7 to 62.2; 3.1)	57.2 (50.3 to 64.1; 3.5)	<0.0001
Depressive symptoms	48.5 (42.8 to 54.2; 2.9)	49.3 (43.7 to 54.9; 2.8)	53.5 (47.4 to 59.7; 3.1)	<0.0001
Pain interference	41.0 (35.3 to 46.6; 2.9)	45.8 (40.3 to 51.4; 2.8)	55.7 (49.4 to 62.1; 3.2)	<0.0001
Fatigue	52.1 (45.8 to 58.3; 3.1)	56.4 (50.3 to 62.6; 3.1)	65.7 (58.9 to 72.6; 3.4)	<0.0001
Peer relationships	48.2 (42.0 to 54.3; 3.1)	46.8 (40.8 to 52.9; 3.1)	42.9 (36.4 to 49.4; 3.1)	<0.0001

Measured by Pediatric Ulcerative Colitis Disease Activity Index (PUCAI). Disease activity categories as follows: Remission = PUCAI score <10; Mild = PUCAI score 10–34; Moderate/Severe = PUCAI score 35–85

^**

Lower scores in anxiety, depression, pain interference, and fatigue indicate improvements in health and/or functioning. A higher score in peer relationships indicates improved functioning.