Table 3.
Multivariable Cox regression models predicting cancer-specific mortality (CSM) in 4271 upper tract urothelial carcinoma patients identified within Surveillance, Epidemiology and End Results database (2010–2016), where pathological grade was defined according to the two-tier 2004/2016 World Health Organization (WHO) grading system
| CSM | ||
|---|---|---|
| HR (95% CI) | p-value | |
| WHO 2004/2006 grading system, relative to low grade | ||
| High grade | 1.70 (1.23–2.35) | 0.001 |
| T-stage, relative to T1 | ||
| T2 | 1.84 (1.38–2.46) | < 0.001 |
| T3 | 3.61 (2.86–4.56) | < 0.001 |
| T4 | 10.51 (7.92–13.94) | < 0.001 |
| N-stage, relative to N0 | ||
| N+ | 1.82 (1.49–2.23) | < 0.001 |
| NX | 0.79 (0.39–1.60) | 0.5 |
| Chemotherapy administration, relative to no/unknown | ||
| Yes | 0.80 (0.67–0.96) | 0.01 |
| Primary site, relative to renal pelvis | ||
| Ureter | 1.19 (1.01–1.40) | 0.04 |