Table 3.

Sub-networks related to the nervous system, cardiovascular function, and the gastrointestinal system

Gene set seed	Total # of neighbors	# of Measured neighbors	Median change	P-value	Activation score
Adrenergic transmission	58	13	− 1.05	0.0045	− 1
Cardiovascular deconditioning	200	66	1.05	0.01	− 0.45
Cardiovascular function	325	123	1.04	0.00038	− 0.45
Cardiovascular physiology	61	22	1.04	0.036	1
Central nervous system function	276	104	1.01	0.015	0
Cholinergic synaptic transmission	125	40	− 1.008	0.00066	1.13
Dopaminergic activity	99	29	− 1.02	0.036	0.58
Dopaminergic transmission	140	51	1.04	0.0059	− 1.34
Enteric nervous system	188	82	− 1.07	0.0001	− 1
Gastrointestinal function	120	39	− 1.01	0.0078	− 1
Long-term synaptic depression	439	206	1.02	0.02	− 1.28
Nerve regeneration	498	216	− 1.03	2.25E−07	0.17
Nervous system physiology	529	218	− 1.07	5.89E−09	− 1
Neuromodulation	105	31	− 1.09	0.023	Unknown
Neuron development	370	143	− 1.03	0.00034	− 1.26
Neuron differentiation	316	122	− 1.04	0.0043	0
Neuron sensitivity	90	30	1.05	0.015	0.45
Neuronal activity	699	275	1.02	1.40E−06	− 1.4
Neuronal death	1535	828	− 1.03	0.0056	0
Renin–angiotensin system	257	104	1.05	0.017	− 1.51
Synaptic plasticity	1226	603	1.02	0.0006	0.17

Provided in the table is the gene set seed, number of entities measured in the pathway, the median fold change, the P-value, and the activation score for the network. Transcriptome data for gut epithelial cells were obtained from Yang et al. (2020)