Table 1.
Loci associated with bovine coronavirus infection across populations.
| BTAa | Locus range (Bb) | Lead SNP IDb | # SNP in locus | Population(s)c | Model(s) | Positional candidate gene(s)d |
|---|---|---|---|---|---|---|
| 18 | 5,420,736–5,749,984 | rs109736099 | 3 | C & F | Recessive | WWOX |
| 19 | 8,294,507–8,360,868 | rs134736482 | 3 | C & D | Recessive | MSI2 |
| 19 | 62,757,064–62,763,041 | rs41926279 | 2 | C & F | Recessive | PRKCA |
Single-nucleotide polymorphism (SNP) location as measured by numbered nucleotides in reference to the ARS 1.2 genome assembly (https://www.animalgenome.org/repository/cattle/UMC_bovine_coordinates/; accessed 21, January 2020).
Most significant SNP in each locus is identified by rs number which is a reference number assigned to markers submitted to the National Center for Biotechnology Information SNP database.
Populations abbreviated as follows: C, combined feedlot and dairy; F, feedlot; D, dairy.
Positional candidate genes are defined as genes that are located within the average haplotype block range (combined = 15 kb; feedlot = 12 kb; dairy = 18 kb) on either side of the associated SNP(s) or had the significant SNP located within the gene itself (bolded).