FIGURE 1.

Upregulated SETD1A is associated with the disease process in lung cancer. (a) The mRNA levels of SETD1A with different SETD1A DNA copy numbers in lung cancer. (Shallow deletion, n = 79; diploid, n = 260; gain, n = 158; amplification, n = 6). Data were from the cBioportal database. (b) Lung adenocarcinoma and adjacent nontumor lung tissue were analyzed using the Illumina human WG‐6 v3.0 expression Beadchip and the expression of SETD1A between the two groups was determined (GEO DataSets, GSE32863, n = 58). (c) SETD1A mRNA levels in different stages of lung adenocarcinoma from a public dataset (GEO DataSets, GSE32863. Normal, n = 58; stage I, n = 34; stage II, n = 11; stage III/IV, n = 13). (d) Fold‐change of SETD1A levels in lung cancer cell lines compared to small airway epithelial cell (SAEC). Data were from previous reports.¹² (e) Kaplan–Meier plot of cumulative overall survival of patients with lung carcinoma in the TCGA database. Patients in the 90% (SETD1A higher expression group, blue line, n = 440) were compared with patients in the lower 10% (SETD1A lower expression group, yellow line, n = 48). The p‐value of the log‐rank test comparing the two survival curves was 0.067. Statistical test of (a)–(c) were analyzed by using the Welch's t‐test after log transformation. n means independent biological sample