Table 2.

Genotype distribution and chi-square analysis in the discovery stage.

SNP	Gene	Major allele/minor allele	Controls (N = 435)a	AD patients (N = 435)a	p-value*
rs13019803	IL1R1	C/T	0.176	0.120	9.30E−04
rs2241132	IL1RL2	C/A	0.300	0.272	0.200
rs4988958	IL1RL1	T/C	0.131	0.154	0.175
rs11692304	SLC9A4	G/A	0.181	0.203	0.262
rs6751967	IL1RL1	T/C	0.133	0.151	0.283
rs2241116	IL18R1	C/A	0.179	0.174	0.784
rs3917296	IL1R1	A/G	0.152	0.174	0.209
rs3917254	IL1R1	G/A	0.236	0.201	0.077
rs1468788	SLC9A4	C/T	0.223	0.202	0.279
rs887971	IL18RAP	T/C	0.321	0.293	0.222
rs4851608	SLC9A4	C/T	0.320	0.315	0.836
rs4241211	SLC9A4	T/G	0.439	0.445	0.805
rs10167431	IL1RL2	C/T	0.338	0.352	0.565
rs1921622	IL1RL1	G/A	0.366	0.354	0.597
rs17775170	SLC9A2	G/A	0.181	0.174	0.690
rs3771172	IL18R1	C/T	0.306	0.264	0.054
rs3821204	IL1RL1	C/G	0.312	0.275	0.086
rs1558650	IL18RAP	T/A	0.459	0.449	0.703
rs12712135	IL1RL1	A/G	0.456	0.485	0.234

^*Significant after Bonferroni correction for 19 tests (p <0.0026).

^aMinor allele frequencies.

AD, aortic dissection.