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. 2021 Aug 2;8:706924. doi: 10.3389/fcvm.2021.706924

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Copyright © 2021 Wang, Xing, Liu, Gao, Liu, Li, Hu, Zhao, Liao, Liu and Dong.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Insulin resistance in WT and Seipin deleted mice. (A) Plasma triglyceride (TG), total cholesterol (TC), glucose content in mice fasted for 4 h. (B) Free fatty acid (FFA) in mice fasted for 4 h. (C) Plasma levels of IL-6, TNF-α in mice fasted for 4 h. (D) Plasma insulin, leptin, adiponectin content in mice fasted for 4 h. (E) Glucose tolerance tests and insulin tolerance tests (F) performed on 6-month-old Seipin^−/− and WT mice. Data are expressed as mean ± SEM. N = 6. ^*P < 0.05, ^**P < 0.01 for Seipin^−/− mice vs. WT.