表 1.
患者临床组织病理学资料及与疾病进展相关单因素分析
Clinicopathological data and univariate analysis of disease progression
| Characteristics | Progression free (n=128, 66.7%) | Progression (n=64, 33.3%) | P |
| CCRCC，clear cell renal cell carcinoma; BMI, body mass index; PLT, platelet count; MPV, mean platelet volume; PDW, platelet distribution width; * selected into multivariate analysis. | |||
| Age/years, x±s | 59.8±12.7 | 58.6±8.6 | 0.490 |
| Gender, n(%) | |||
| Male | 87 (68) | 46 (71.9) | 0.622 |
| Female | 41 (32) | 18 (28.1) | |
| Symptom at presentation, n(%) | 35 (27.3) | 38 (59.4) | < 0.001* |
| BMI/(kg/m2)，x±s | 25.4±3.5 | 24.7±3.3 | 0.135 |
| Comorbidities, n(%) | |||
| Hypertension | 54 (42.2) | 29 (45.3) | 0.758 |
| Diabetes mellitus | 26 (20.3) | 6 (9.4) | 0.065 |
| Surgical approach, n(%) | |||
| Open | 50 (39.1) | 29 (45.3) | 0.439 |
| Laparoscopic | 78 (60.9) | 35 (54.7) | |
| Surgical time/min, x±s | 193.60±94.03 | 276.23±130.14 | < 0.001 |
| Interoperative blood loss/mL, x±s | 359.53±951.83 | 711.72±1 063.19 | 0.027 |
| Tumor side, n(%) | 1.000 | ||
| Left | 69 (53.9) | 34 (53.1) | |
| Right | 59 (46.1) | 30 (46.9) | |
| Tumor size/cm, x±s | 6.6±3.7 | 7.1±2.8 | 0.345 |
| Histologic subtype, n(%) | 0.649 | ||
| CCRCC | 113 (88.3) | 55 (85.9) | |
| Non-CCRCC | 15 (11.7) | 9 (14.1) | |
| Nuclear grade, n(%) | < 0.001* | ||
| Ⅰ to Ⅱ | 86 (67.2) | 27 (42.2) | |
| Ⅲ to Ⅳ | 32 (25) | 36 (56.3) | |
| Unknow | 10 (7.8) | 1 (1.6) | |
| Necrosis, n(%) | 27 (21.1) | 33 (51.6) | < 0.001* |
| Sarcomatoid differentiation, n(%) | 4 (3.1) | 7 (10.9) | 0.044* |
| Rheumatoid differentiation, n(%) | 5 (3.9) | 5 (7.8) | 0.305 |
| Lymphovascular invasion, n(%) | 14 (10.9) | 17 (26.6) | 0.011* |
| Renal sinus invasion, n(%) | 95 (74.2) | 47 (73.4) | 1.000 |
| Perirenal fat invasion, n(%) | 30 (23.4) | 23 (35.9) | 0.087 |
| Urinary collecting system invasion, n(%) | 3 (2.3) | 5 (7.8) | 0.120 |
| Venous tumor thrombus, n(%) | 37 (28.9) | 38 (59.4) | < 0.001* |
| Lymph node invasion, n(%) | 2 (1.6) | 6 (9.4) | 0.018* |
| Adrenal invasion, n(%) | 4 (3.1) | 6 (9.4) | 0.086 |
| SSIGN score, n(%) | 0.013 | ||
| 0－3 | 46 (35.9) | 12 (18.8) | |
| 4－6 | 73 (57) | 41 (64.1) | |
| 7－11 | 9 (7) | 11 (17.2) | |
| Platelet indices | |||
| PLT/(×109/L)，x±s | 227.27±66.94 | 250.72±88.59 | 0.042* |
| MPV/fL, x±s | 10.12±1.26 | 9.96±0.97 | 0.394 |
| PDW/%, x±s | 13.31±2.74 | 12.01±2.27 | 0.001* |