Table 4.

Recommendations for secure iPSC data management

#	Guidance 5. Recommendations for iPSC data management
Data type		Solutions
5.1	Donor sample nomenclature	Implement robust procedures for assigning pseudonymized/anonymized identifiers for donor samples. Properties associated with assigned samples such as anonymized donor ID, age at sample collection, sex, and disease diagnosis should be carefully recorded within a secure internal database. Most importantly, the paper trail of consent to the sample donation must be kept intact. As long as accurate records are thus maintained, the sample ID can be a simple institutional identifier with increasing numerical digits; e.g., XY1, XY2
5.2	IPSC line nomenclature	Implement robust procedures for assigning pseudonymized/anonymized identifiers for early reprogrammed clones and iPSC lines, using established tools such as hPSCreg wherever possible
5.3	Batch identifiers	Implementation of a simple identifier system for cell line batches (or lots)
5.4	Vial labeling	Use of unique printed labels that are suited to low temperatures, long-term liquid nitrogen storage, printed using indelible ink, with machine-readable barcodes and human-readable identifiers
5.5	Donor demographics and basic clinical data	Submission of cell line data to hPSCreg
5.6	Detailed clinical datasets and genomic datasets	Submission of data to a local secure managed access data repository, many of which are available internationally, such as the European Genome-Phenome Archive or the NIH-NCBI Database of Genotypes and Phenotypes
5.7	Day-to-day iPSC handling	Using standard forms for day-to-day data collection increases standardization of what and how data are captured when being performed by multiple people, minimizing variabilities. Formal laboratory notebooks can take this role; however, it is key that the data points recorded are standardized. Key reagents (media, matrix, dissociation agents, etc.) should be logged, including lot number and expiry date. Morphology, confluency, split ratio/seeding density, and passage number should also be recorded. Summary details (such as passaging method) are recorded in hPSCreg