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Issues in Developing a Serological Test for Neisseria gonorrhoeae
| Identification of target antigen(s): |
| Expressed by all/most strains of N. gonorrhoeae |
| Preferably constitutive |
| Relatively abundant |
| Immunogenic during natural infection |
| Unique to N. gonorrhoeae |
| Not present in N. meningitidis or commensal Neisseria sp. |
| N. gonorrhoeae suppresses adaptive immune responses, ie, antibodies |
| More information required about responses in complicated upper tract infection |
