Table 1.

Mediator Gene Functions and Directionality

Overall Function	Gene Name	Specific Function	Expression in Endo+ Versus Endo− Women	Citation
Innate Immune Response
	ABR	Regulation of inflammation	↑	[26]
	ASB13	Innate immune response regulator	↑	[27]
	TLR3a	Type I interferon induction	↑	[28]
	NPR2	C-type natriuretic peptide receptor which inhibits IFN-γ mediated gene expression	↑	[20]
	PSG3	IFN-γ responsiveness	↑	[29]
	PVR (CD155)	NK cell effector function	↑	[30]
	Mir620	Targets CCL2 (MCP-1)	↑	[31]
	COG6	Regulation of inflammation	↓	[32]
	MEIS2	Myeloid cell differentiation	↓	[33]
	PSG2	IDO and TGF-β activity	↓	[34]
	SLC5A1	Glucose transport; innate immune cell function	↓	[35]
Adaptive Immune Response
	PFKP	Glycolysis; T-cell function	↑	[23]
	TLR3a	T-cell activation	↑	[36]
	LARGE	T-cell development	↓	[24]
	LGMN	T-cell activation; Class II antigen presentation	↓	[25]
Fibrosis
	PLOD2	Fibrotic enzyme	↑	[37]
	TLR3a	Wound healing, fibrosis	↑	[38]
Proliferation and Apoptosis
	CSE1L	Cell proliferation	↓	[39]
	HERPUD1	Apoptosis regulation	↓	[40]
	TMEM192	Apoptosis regulation	↓	[41]
	XRN1	Mitochondrial function	↓	[42]
Protein Synthesis and Degradation
	ASB13	Protein degradation	↑	[43]
	HERPUD1	Destruction of misfolded proteins	↓	[44]
	MRM1	Ribosomal RNA transferase	↑	[45]
	MTRF1	Mitochondrial translation	↑	[46]
	UROS	Methionine synthesis	↑	[47]
	WDR33	Protein synthesis; cell differentiation	↑	[48]
Gene Regulation
	HELTb	Transcriptional repressor	↓	[40]
	ZNF512	Transcription regulation	↑	[13]
Cell Membrane Formation and Function
	PCDH17	Cell adhesion	↑	[49]
	PIGO	Cell membrane phospholipid synthesis	↑
	SLC26A5	Membrane anion transporter	↑	[50]
	CADPS	Vesicle exocytosis	↓	[s1]
	CEPT1b	Cell membrane phospholipid synthesis	↓	[s2]
	LR2BPb	Ligand endocytosis	↓	[s3]
Intracellular Energy Transfer
	ABR	GTPase	↑	[s4]
	NDUFB4	NADH dehydrogenase	↑	[s5]
Female Reproductive Tract Health
	OVGP1b	Fertilization, implantation, embryonic development	↑	[10]
	NPR2	Female reproductive tract development	↑	[s6]
	GAS2L2	Regulates ciliary orientation	↑	[s7]
Miscellaneous	EMR4	Human pseudogene	↑	[s8]
	RPP38-DT	Unknown function	↑
	FAM162B	Unknown function	↓
	HEATR9	Unknown function	↓
	KRTAP3-1	Keratin-associated protein	↓	[s9]

Abbreviations: IDO, indoleamine dioxygenase; IFN, interferon; MCP-1, monocyte chemoattractant protein-1; NK, natural killer; RNA, ribonucleic acid; TGF, transforming growth factor.

^aTLR3 (P < .01) overlapped from primary and secondary analyses coincident with loci for chlamydial ascension.

^bMediator genes (P < .01) from primary analysis of Centers for Disease Control and Prevention (CDC) cohort (P < 5 × 10E-05) coincident with loci for chlamydial ascension.

NOTE: The remaining mediator genes (P < .01) are from secondary analysis of CDC cohort (P < 5 × 10E-03) and Pelvic Inflammatory Disease Evaluation and Clinical Health (PEACH) cohort (P < 5 × 10E-02) coincident with loci for chlamydial ascension.