Table 1.
Association of HE grade with characteristics of AoCLD patients.
| Characteristics | NO HE (N = 3,610) | HE 1 (N = 127) | HE 2 (N = 137) | HE 3 (N = 55) | HE 4 (N = 20) |
|---|---|---|---|---|---|
| Demographic | |||||
| Age | 48.00 (39.81, 57.25) | 53.01 (45.18, 61.08) | 52.51 (44.08, 60.00) | 49.74 (40.45, 61.91) | 51.16 (42.20, 55.66) |
| Gender (male) | 2,638 (73.1) | 101 (79.5) | 112 (81.8) | 44 (80.0) | 15 (75.0) |
| Etiology | |||||
| HBV | 2,600 (72.0) | 74 (58.3) | 87 (63.5) | 26 (47.3) | 11 (55.0) |
| Alcohol | 628 (17.4) | 35 (27.6) | 38 (27.7) | 19 (34.5) | 4 (20.0) |
| Autoimmune | 363 (10.1) | 10 (7.9) | 8 (5.8) | 7 (12.7) | 3 (15.0) |
| HCV | 129 (3.6) | 7 (5.5) | 6 (4.4) | 1 (1.8) | 0 (0.0) |
| HEV | 79 (2.2) | 3 (2.4) | 5 (3.6) | 0 (0.0) | 1 (5.0) |
| NAFLD | 146 (4.0) | 4 (3.1) | 0 (0.0) | 1 (1.8) | 0 (0.0) |
| Schistosomiasis | 48 (1.3) | 4 (3.1) | 2 (1.5) | 1 (1.8) | 0 (0.0) |
| Cryptogenic | 171 (4.7) | 9 (7.1) | 9 (6.6) | 5 (9.1) | 2 (10.0) |
| Cirrhosis status | |||||
| Non_cirrhosis | 1,101 (30.5) | 17 (13.4) | 13 (9.5) | 8 (14.5) | 4 (20.0) |
| Cirrhosis | 2,509 (69.5) | 110 (86.6) | 124 (90.5) | 47 (85.5) | 16 (80.0) |
| Compensated | 224 (6.2) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) |
| Decompensated | 2,285 (63.3) | 110 (86.6) | 124 (90.5) | 47 (85.5) | 16 (80.0) |
| Acute decompensation | |||||
| Infection | 740 (20.5) | 29 (22.8) | 49 (35.8) | 17 (30.9) | 6 (30.0) |
| Jaundice | 1,662 (46.1) | 57 (44.9) | 85 (62.0) | 39 (70.9) | 13 (65.0) |
| Ascites | 1,692 (46.9) | 57 (44.9) | 67 (48.9) | 24 (43.6) | 10 (50.0) |
| GI_Bleeding | 530 (14.7) | 16 (12.6) | 20 (14.6) | 9 (16.4) | 3 (15.0) |
| Laboratory tests | |||||
| TB | 4.13 (1.52, 13.38) | 3.71 (2.18, 16.02) | 10.36 (2.40, 26.21) | 10.07 (3.86, 26.52) | 13.11 (3.44, 23.41) |
| INR | 1.40 (1.17, 1.76) | 1.58 (1.41, 2.22) | 1.84 (1.40, 2.79) | 1.98 (1.48, 2.98) | 2.13 (1.75, 3.01) |
| CR | 0.77 (0.64, 0.93) | 0.78 (0.62, 0.96) | 0.84 (0.66, 1.11) | 0.88 (0.64, 1.32) | 0.78 (0.66, 1.08) |
| BUN | 4.49 (3.40, 6.23) | 5.05 (3.53, 8.02) | 5.99 (4.25, 8.26) | 7.11 (3.82, 15.09) | 7.36 (4.55, 10.74) |
| ALB | 32.30 (28.20, 37.00) | 31.00 (27.00, 34.60) | 30.20 (26.80, 34.30) | 28.30 (26.70, 32.10) | 31.70 (26.45, 35.39) |
| ALT | 100.3 (34.4, 436.0) | 45.2 (23.0, 147.0) | 45.0 (25.7, 140.6) | 57.0 (26.2, 152.2) | 102.3 (39.0, 399.3) |
| AST | 113.0 (49.0, 292.0) | 75.9 (35.3, 181.1) | 76.5 (38.4, 159.8) | 89.0 (46.4, 181.2) | 133.9 (70.0, 251.5) |
| WBC | 4.95 (3.60, 6.86) | 4.91 (3.60, 6.91) | 6.36 (4.09, 9.99) | 6.90 (5.19, 12.01) | 9.44 (6.36, 13.07) |
| PLT | 96.0 (59.0, 148.0) | 78.0 (50.4, 118.5) | 69.0 (48.0, 119.0) | 79.0 (56.5, 128.5) | 84.5 (43.6, 112.2) |
| FIO2 | 476.2 (466.7, 476.2) | 471.4 (461.9,476.2) | 476.2 (466.7, 476.2) | 471.4 (433.3, 476.2) | 466.7 (410.3, 476.2) |
| MAP | 89.00 (83.00, 94.67) | 89.00 (80.66, 96.67) | 87.00 (82.00, 94.00) | 90.00 (76.84, 96.34) | 94.50 (87.83, 101.75) |
| AKP | 127.0 (91.0, 172.0) | 116.0 (94.0, 163.4) | 121.7 (83.7, 162.1) | 117.2 (83.4, 161.2) | 113.0 (80.0, 158.5) |
| γ-GT | 82.00 (40.05, 155.88) | 60.00 (25.50, 115.00) | 48.00 (25.23, 93.40) | 44.00 (30.60, 92.60) | 54.90 (33.50, 69.50) |
| NL_ratio | 2.46 (1.54, 4.24) | 3.03 (1.81, 5.43) | 4.33 (2.64, 7.74) | 5.61 (3.23, 7.83) | 9.03 (4.43, 11.72) |
| Hemoglobin | 118.0 (97.0, 136.0) | 113.0 (92.5, 128.5) | 108.0 (84.0, 129.0) | 98.0 (78.6, 120.5) | 109.7 (97.2, 130.7) |
| Neutrophil | 2.99 (1.99, 4.55) | 3.10 (2.17, 5.12) | 4.57 (2.46, 7.76) | 5.39 (3.15, 9.03) | 7.18 (4.25, 10.88) |
| Lymphocyte | 1.22 (0.81, 1.75) | 1.09 (0.76, 1.46) | 1.00 (0.68, 1.50) | 1.19 (0.70, 1.83) | 0.96 (0.71, 1.12) |
| K | 3.87 (3.52, 4.20) | 3.81 (3.50, 4.12) | 3.82 (3.41, 4.28) | 4.00 (3.70, 4.39) | 3.75 (3.14, 4.16) |
| Na | 138.3 (135.7, 141.0) | 137.9 (135.0,140.9) | 136.0 (133.0, 141.0) | 135.2 (131.3, 139.0) | 138.7 (135.0, 141.5) |
| Scores | |||||
| MELD | 15.50 (10.00, 22.00) | 16.00 (12.00, 27.00) | 21.50 (13.75, 30.25) | 24.50 (18.00, 33.75) | 23.00 (17.00, 31.00) |
| MELD_Na | 17.00 (11.00, 24.00) | 19.00 (13.00, 29.00) | 24.00 (15.00, 32.00) | 27.00 (16.00, 35.00) | 22.00 (16.00, 33.00) |
| IMELD | 34.00 (27.00, 41.00) | 37.00 (30.00, 45.00) | 41.00 (34.00, 50.50) | 47.00 (35.00, 56.00) | 42.00 (34.50, 47.50) |
| CLIF_SOFA | 5.00 (3.00, 6.00) | 6.00 (5.00, 8.00) | 9.00 (6.75, 9.00) | 10.00 (8.00, 11.75) | 11.00 (9.00, 12.00) |
| SOFA | 8.00 (7.00, 9.00) | 9.00 (8.00, 10.00) | 10.00 (9.00, 11.00) | 10.00 (9.00, 11.00) | 9.00 (8.00, 11.50) |
| CHILD_PUGH | 8.00 (7.00, 10.00) | 10.00 (8.00, 11.75) | 11.00 (9.00, 12.00) | 12.00 (11.00, 13.00) | 11.50 (11.00, 13.00) |