Table 4.

Odds ratios and p-values of HE grades in the total population at day 28.

HE_GRADE	Num of 28-day adverse outcome (%)	Model I	Model II	Model III	Model IV
NO HE	351 (9.7)	1.0	1.0	1.0	1.0
1	23 (18.1)	2.05 (1.26, 3.20) 0.0024	1.99 (1.21, 3.13) 0.003	1.95 (1.18, 3.10) 0.005	1.47 (0.85, 2.46) 0.146
2	35 (25.5)	3.18 (2.11, 4.70) <0.0001	3.10 (2.04, 4.60) <0.0001	2.77 (1.82, 4.15) <0.0001	1.16 (0.68, 1.89) 0.563
3	26 (47.3)	8.32 (4.82, 14.30) <0.0001	8.76 (5.02, 15.21) <0.0001	8.80 (4.97, 15.54) <0.0001	4.03 (2.06, 7.78) <0.0001
4	13 (65.0)	17.24 (7.01, 46.15) <0.0001	18.76 (7.57, 50.58) <0.0001	19.04 (7.51, 52.44) <0.0001	16.74 (5.81, 52.31) <0.0001

Model I, unadjusted.

Model II, adjusted for age, sex, and etiology.

Model III, adjusted for model II plus cirrhosis, ascites, infection, and gastrointestinal bleeding.

Model IV, adjusted for model III plus total bilirubin, international normalized ratio, and creatinine.