Table 5.

Odds ratios and p-values of HE grades in the total population at day 90.

HE_GRADE	Num of 90-day adverse outcome (%)	Model I	Model II	Model III	Model IV
NO HE	594 (16.5)	1.0	1.0	1.0	1.0
1	36 (28.3)	2.00 (1.34, 2.97) 0.0004	1.95 (1.29, 2.88) 0.003	1.95 (1.28, 2.91) 0.0014	1.46 (0.90, 2.32) 0.11
2	52 (38.0)	3.00 (2.10, 4.30) <0.0001	2.94 (2.04, 4.20) <0.0001	2.66 (1.82, 3.83) <0.0001	1.15 (0.72, 1.81) 0.54
3	32 (58.2)	7.10 (4.14, 12.34) <0.0001	7.26 (4.21, 12.73) <0.0001	7.65 (4.35, 13.56) <0.0001	3.37 (1.71, 6.64) 0.0004
4	14 (70.0)	11.90 (4.75, 33.70) <0.0001	12.66 (5.03, 35.99) <0.0001	13.07 (5.05, 38.10) <0.0001	10.56 (3.53, 35.62) <0.0001

Model I, unadjusted.

Model II, adjusted for age, sex, and etiology.

Model III, adjusted for model II plus cirrhosis, ascites, infection, and gastrointestinal bleeding.

Model IV, adjusted for model III plus total bilirubin, international normalized ratio, and creatinine.