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. 2021 Jul 12;40(16):e108293. doi: 10.15252/embj.2021108293

Figure 3. Recognition of the nucleosome acidic patch by cGAS and other binders via an arginine anchor.

Figure 3

Top: Surface electrostatics representation of the cGAS–nucleosome complex (PDB code 7A08) and close‐ups of different arginine anchor interactors with the acidic patch at the interface between histones H2A‐H2B (yellow, red). cGAS (blue, PDB code 7A08), RCC1 (pink, PDB code 3MVD). Bottom: Surface electrostatics representation of two stacked NCPs and close‐up of H4 tail interactions from NCP1 with NCP2 (gray, PDB code 1AOI).