Table 2.
Estimates of declining rate of CD4 T cell counts from the time of diagnosis to cART initiation
| HIV-1 subtype | N | Decline rate (cell/µl)1/2 /year) | Decline rate (cell/µl)1/2/year) | |||
|---|---|---|---|---|---|---|
| Mean (95%CI) | P value | P value | Adjusted mean (95%CI)* | P value | ||
| CD4 200–350 | ||||||
| CRF55_01B | 62 | 13.6 (8.3, 18.9) | Ref | Ref | Ref | |
| CRF01_AE | 157 | 23.3 (15.9, 30.7) | < 0.05 | Ref | 10.3 (0.7, 19.9) | < 0.05 |
| CRF07_BC | 194 | 11.0 (8.4, 13.5) | 0.391 | < 0.01 | − 2.7 (− 12.0, 6.6) | 0.570 |
| CD4 ≥ 350 | ||||||
| CRF55_01B | 52 | 7.9 (3.0, 12.8) | Ref | Ref | Ref | |
| CRF01_AE | 114 | 6.9 (5.0, 8.8) | 0.702 | Ref | 1.4 (− 3.5, 6.2) | 0.587 |
| CRF07_BC | 174 | 9.6 (5.6, 13.6) | 0.597 | 0.226 | 0.7 (− 4.1, 5.5) | 0.776 |
| All ≥ 200 | ||||||
| CRF55_01B | 114 | 11.0 (7.3, 14.7) | Ref | Ref | Ref | |
| CRF01_AE | 271 | 16.4 (11.9, 20.9) | 0.069 | Ref | 6.0 (− 0.3, 12.3) | 0.064 |
| CRF07_BC | 368 | 10.3 (8.0, 12.7) | 0.77 | < 0.05 | − 0.6 (− 6.7, 5.4) | 0.837 |
* The Adjusted mean was estimated with adjustment of age at HIV diagnosis, ethnicity, marital status, and year of HIV diagnosis