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. 2021 Aug 2;13:697621. doi: 10.3389/fnagi.2021.697621

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Copyright © 2021 Yanai and Endo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Locomotor activity decreases with increasing age in novel and familiar environments. Mean distance traveled and number of rearings of the different age cohorts in novel (open field) environment under low (dark) and high (bright) illumination and familiar (home cage) environment. In the open field test, (A) distance traveled and (B) number of rearings decreased significantly with increasing age and under both illumination conditions. (C) In the familiar environment of the home cage (sixth day), distance traveled decreased significantly with increasing age. ^∗∗∗p < 0.001.