TABLE 2.

Base set of traits for human aging phenotype, corresponding mouse traits, and operational measures for each trait.

Human aging phenotype	Mouse behavioral trait	Operational measure	References for human literature
-Unintentional weight loss	-Body weight	-Body weight*	Fryar et al., 2016 (Body weight)
-Reduced activity	-Locomotor activity	-Open field test -Home cage activity*	Tveter et al., 2014 (6-min walking test)
-Slowness	-Maximum gait velocity	-Rotor rod test*	Bohannon and Andrews, 2011 (Gait velocity)
-Weakness	-Grip strength	-Wire hanging test*	Bohannon et al., 2006 (Hand grip strength)
-Trait anxiety	-Anxiety	-Open field test* -Marble burying test	Tomitaka et al., 2015 (CES-D)
-Cognitive impairment	-Spatial memory	-Barnes maze -Morris water maze task*	Rossetti et al., 2011 (MoCA)
-Cognitive impairment	-Associative memory	-Pavlovian fear conditioning task	n/a

*Representative data for each behavioral trait of mouse is indicated by asterisk.

CES-D, Center for Epidemiological Studies – Depression scale; MoCA, Montreal Cognitive Assessment; n/a, not available.