Table 4.
Multiplex and Xpert MTB/RIF diagnostic performances relative to sputum culture.
| Multiplex RT-PCR | Xpert MTB-RIF | ||
|
All participants (N=190) |
|||
| Sensitivity (%) [CI] | 80·4 [66·8-89·3] | 93·4 [82·85-97·7] | |
| Specificity (%) [CI] | 85·7 [77·7-91·1] | 61·9 [52·3-70·6] | |
| PPV (%) [CI] | 71·1 [57·7-81·6] | 51·8 [41·2-62·2] | |
| NPV (%) [CI] | 90·9 [83·6-95·1] | 95·5 [87·8-98·4] | |
| TB Patient Naïve to treatment (N=30) | Sensitivity (%) [CI] | 82·4 [58·9–93·8] | 94·1 [73·0–98·9] |
| Specificity (%) [CI] | 90·9 [62·2–98·3] | 81·8 [52·3–94·8] | |
| PPV (%) [CI] | 93·3 [70·1–98·8] | 88·9 [67·2–96·9] | |
| NPV (%) [CI] | 76·9 [49·7–91·8] | 90.0 [59·5–98·2] | |
| HIV Patient (N=36) | Sensitivity (%) [CI] | 71·4 [52·9–84·7] | 96·4 [82·2–99·3] |
| Specificity (%) [CI] | 96·2 [81·1–99·3] | 76.9 [57·9–88·9] | |
| PPV (%) [CI] | 95·2 [77·3–99·1] | 81·8 [65·6–91·3] | |
| NPV (%) [CI] | 75·8 [58·9 – 87·1] | 95·2 [77·3–99·1] | |
| Treatment failure, retreatment and NTM suspected patients (N=77) | Sensitivity (%) [CI] | 75·0 [50·5-89·8] | 87·5 [63·9-96·5] |
| Specificity (%) [CI] | 71·1 [56·6-82·2] | 37·7 [25·1-52·3] | |
| PPV (%) [CI] | 48·0 [30·0-66·5] | 33·3 [21·0-48·4] | |
| NPV (%) [CI] | 88·8 [74·6-95·5] | 89·4 [68·6-97·0] | |
| All (without treatment failure participants) (N=113) | Sensitivity (%) [CI] | 83·3 [66·4-92·6] | 96·7 [83·3-99·4] |
| Specificity (%) [CI] | 96·6 [88·6-99·0] | 80·0 [68·2-88·1] | |
| PPV (%) [CI] | 92·5 [82·3-96·5] | 70·7 [55·5-82·3] | |
| NPV (%) [CI] | 92·2 [82·7-96·5] | 97·9 [89·3-99·6] | |
CI: confidence Interval; PPV: Positive Predictive Value; NPV: Negative Predictive Value