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. 2021 Jul 30;24(4):689. doi: 10.3892/mmr.2021.12330

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Copyright: © Hu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 1. — miR-351-5p antagomir alleviates LPS-induced ALI. (A and B) Relative miR-351-5p levels in the lungs (n=6). (C) Lung histopathology determined by hematoxylin and eosin staining (n=6). (D) LDH activity in the lungs with or without miR-351-5p antagomir treatment upon LPS challenge (n=6). (E) Lung W/D ratio (n=8). (F) Total protein concentrations in bronchoalveolar lavage fluids (n=6). (G-I) Quantification of respiratory functional parameters, including tidal volume, lung compliance and respiratory rate (n=6). (J and K) Quantification of PaO₂ and PaCO₂ during arterial blood gas analysis (n=6). (L) Survival analysis of mice with or without miR-351-5p antagomir treatment upon LPS challenge (n=20). All data are expressed as mean ± SD. *P<0.05 with comparisons shown by lines. miR, microRNA; LPS, lipopolysaccharide; ALI, acute lung injury; LDH, lactate dehydrogenase; W/D, wet/dry weight; PaO₂, partial pressure of oxygen; PaCO₂, partial pressure of carbon dioxide; NC, negative control.