Figure 5.

circCD151 promotes the proliferation, migration and invasion of lung cancer through the miR-30d-5p/GLI2 axis. Reverse transcription-quantitative PCR detection of GLI2 expression in (A) A549 and (B) NCI-H292 following overexpression of circCD151 and co-transfection of miR-30d-5p mimics. CCK-8 experiment to detect cell proliferation ability of (C) A549 cells and (D) NCI-H292 cells overexpressing circCD151 and co-transfected with miR-30d-5p mimics. Transwell assay to detect cell invasion ability of (E) A549 and (F) NCI-H292 cells overexpressing circCD151 and co-transfected with miR-30d-5p mimics. Data are presented as the means ± standard deviation. *P<0.05; **P<0.01. Circ, circular RNA; miR, microRNA; NC, negative control.