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Schematic depictions of the structural organization of the transmembrane CS-PG receptors CD47 showing its interactions with macrophages, integrins and thrombospondin-1 (TSP-1) (A), betaglycan dimer (B) and endocan (C). Betaglycan forms an active dimer on the cell surface. Protease cleavage sites are indicated which release fragments of the betaglycan ecto-domain. Endocan has an EGF-like and a phenylalanine rich domain and a single CS/DS GAG chain attached to its C-terminus.
