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. 2021 Aug 2;9:696640. doi: 10.3389/fcell.2021.696640

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Copyright © 2021 Hayes and Melrose.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic representation of the structural organization of neural cell adhesion molecules that act as CS-PG receptors (A–C), and the neural NgR1 (D) and ephrin receptors (E) where binding of CS-PGs results in an inhibitory signal to the neuron. Ephrin acts as a receptor for Neuroglycan-C, while phosphacan binds to Contactin-1 (B) and NrCAM (C). LAR acts as a receptor for several CS-PGs. Oligodendrocyte-neuronal communication mediated by LAR-NrCAM (Condomitti and de Wit, 2018) or LAR-contactin-1 interactions (Zhang P. et al., 2018) can be regulated by competitive binding of CS-PGs to these cell surface components (F).