Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Aug 16;13:131. doi: 10.1186/s13073-021-00948-1

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

PMC Copyright notice

Fig. 3 — Transcriptomic profiling of circulating monocytes in the acute and recovery stage of community-acquired pneumonia. A Principal component (PC) plot depicting PC1 and PC2 of 32,630 transcripts of monocytes sampled from CAP patients (acute, n = 75; recovery, n = 59) and control subjects (n = 41). B, C Volcano plot representation (integrating log2 fold change and multiple-comparison adjusted p values) of genome-wide alterations in RNA expression of CAP patient monocytes obtained during (B) the acute stage, and (C) recovery stage, relative to control monocytes. *upregulated genes, absolute fold expression >1.5 and adjusted p<0.01; *downregulated genes, absolute fold expression ≤1.5 and adjusted p<0.01. D Bar plots illustrating significantly enriched ingenuity’s canonical signaling pathways in acute stage monocytes. E Heatmaps of upregulated genes and downregulated genes involved in specific, significant canonical signaling pathways in acute stage monocytes relative to control subjects