Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Jul 29;24(4):684. doi: 10.3892/mmr.2021.12323

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright: © Cao et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

PMC Copyright notice

Figure 3. — circ-PVT1 is upregulated in A549/DDP cells and is involved in DDP-induced apoptosis. (A) The mRNA levels of circ-PVT1 in A549 and A549/DDP cells were measured via reverse transcription-quantitative PCR. *P<0.05 vs. A549 group. (B) The expression of circ-PVT1 in A549/DDP cells after knockdown of circ-PVT1. **P<0.01 vs. Control group; ^##P<0.01 vs. shRNA-NC group. (C) The cell viability of A549/DDP cells after treatment with different concentrations of DDP was measured. **P<0.01 and ***P<0.001 vs. Control group; ^#P<0.05 and ^##P<0.01 vs. shRNA-NC group. (D) The activity of caspase-3 was measured after knockdown of circ-PVT1 in A549/DDP cells. *P<0.05 and ***P<0.001 vs. Control group; ^#P<0.05 and ^###P<0.001 vs. shRNA-NC group. (E) The expression of circ-PVT1 was detected after circ-PVT1 was overexpressed in A549 cells. ***P<0.001 vs. Control group; ^###P<0.001 vs. Oe-NC group. (F) The cell viability of A549 cells after treatment with different concentrations of DDP was measured. ^#P<0.05 vs. Oe-NC group. (G) The activity of caspase-3 was measured after circ-PVT1 was overexpressed in A549 cells. ***P<0.001 vs. Control group; ^###P<0.001 vs. Oe-NC group. circ-PVT1, circular RNA plasmacytoma variant translocation 1; DDP, cisplatin; shRNA, short hairpin RNA; NC, negative control; Oe, overexpression.