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. 2021 Jul 29;24(4):684. doi: 10.3892/mmr.2021.12323

Figure 5.

Figure 5.

FOXK1 is a target of miR-429. The putative binding sites between FOXK1 and hsa-miR-429 were (A) predicted and (B) confirmed via a dual-luciferase reporter assay. **P<0.01 vs. mimic-NC + FOXK1 group. (C and D) The expression of FOXK1 in human normal BEAS-2B and human lung adenocarcinoma cells was measured via RT-qPCR and western blotting. **P<0.01 and ***P<0.001 vs. BEAS-2B group. (E and F) The expression of FOXK1 after miR-429 overexpression in A549 cells was measured via RT-qPCR and western blotting. **P<0.01 vs. Control group; #P<0.05 and ##P<0.01 vs. mimic-NC group. (G and H) The expression of FOXK1 after knockdown of circ-PVT1 expression in A549 cells was measured via RT-qPCR and western blotting. *P<0.05 vs. Control group; #P<0.05 vs. shRNA-NC group. FOXK1, forkhead box k1; miR, microRNA; NC, negative control; RT-qPCR, reverse transcription-quantitative PCR; circ-PVT1, circular RNA plasmacytoma variant translocation 1; shRNA, short hairpin RNA; WT, wild-type; MUT, mutant.