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. 2021 Jul 19;64(15):11496–11526. doi: 10.1021/acs.jmedchem.1c00806

Figure 1.

Figure 1

Correlation network of the compound library for inhibition of 5-LOX in PMNL. The network visualizes structural similarity between compounds calculated using Tanimoto similarity. Nodes represent individual compounds, and connecting edges represent Tanimoto coefficients > 0.9. The node shape differentiates between derivatives derived from amplexichromanols (AC), garcinoic acids (GA), or other leads, and the filling highlights the parental series, i.e., amplexichromanol (red), garcinoic acid (blue), tocopherol, and tocotrienol (green). The node size reflects the potency (IC50 values) of the compound to inhibit 5-LOX product formation in PMNL. For nodes with dotted lines, IC50 values were not determined.