Correlation
network of the compound library for inhibition of 5-LOX
in PMNL. The network visualizes structural similarity between compounds
calculated using Tanimoto similarity. Nodes represent individual compounds,
and connecting edges represent Tanimoto coefficients > 0.9. The
node
shape differentiates between derivatives derived from amplexichromanols
(AC), garcinoic acids (GA), or other leads, and the filling highlights
the parental series, i.e., amplexichromanol (red),
garcinoic acid (blue), tocopherol, and tocotrienol (green). The node
size reflects the potency (IC50 values) of the compound
to inhibit 5-LOX product formation in PMNL. For nodes with dotted
lines, IC50 values were not determined.