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. 2021 Jul 19;64(15):11496–11526. doi: 10.1021/acs.jmedchem.1c00806

Figure 8.

Figure 8

Compound 27a suppresses bronchial hyperreactivity and pulmonary LT formation in mice sensitized to ovalbumin. (A) Time scale for the experimental asthma model. (B–E) Compound 27a (10 mg/kg) was p.o. administered to mice prior to injection of ovalbumin (OVA) on days 0 and 7. (B) Concentrations of 27a in plasma (nM) and lung (pmol/g lung tissue). (C) Pulmonary levels of LTB4 and its isomers on day 3 in pg/mg lung tissue. (D, E) Bronchial reactivity to carbachol (D) or salbutamol (E) on day 21. Data are expressed as mean with single values (C) or mean ± SEM (B, D, E) from n = 5 (B, days 1–10, C), n = 6 (B, day 21), n = 7 (E, OVA, OVA + 27a), n = 8 (D, OVA + 27a), n = 11 (D, OVA, E, control), and n = 12 (D, control) mice. ns, not significant; ***p < 0.001 vs control or as indicated; two-tailed unpaired t-test of log data (C), two-way ANOVA + Bonferroni’s post hoc test (B, D, E).